Mael Gainche
National chemistry school of Clermont-Ferrand, France
Title: Anti-inflammatory activity of new natural compounds from Luzula sylvatica
Biography
Biography: Mael Gainche
Abstract
Anti-inflammatory activity of new natural compounds from Luzula sylvatica
Maël Gainche1 , J Cholet1 , C Ogéron1 , D Fraisse1 , C Felgines1 , M Vareille-Delabre1 , A Berry1 , M Vermerie1 , L Delort1 , C Decombat1 , J-Y Berthon2 , E Ranouille2 , E Saunier3 , J Priam3 , A Tourette4 , F Caldéfie-Chezet1 , F Senejoux1 , I Ripoche1 and P Chalard1 1 Université Clermont Auvergne, France 2 Greentech, France 3 Dômes Pharma, France 4 AltoPhyto, France
Inflammation is one of the major concerns in human health since recent studies highlighted its implication in numerous diseases such as cancer, diabetes or rheumatism. The high complexity of mechanisms involved in inflammation constitutes a real challenge for the discovery of innovative therapeutics. It is now well established that plant kingdom is capable of producing a considerable diversity of secondary metabolites with major medicinal interest. With a flora comprising more than 2000 plant species, the Auvergne region (France) represents a notable hotspot of biodiversity and chemodiversity. In this context, the Plantinauv project was settled to perform biological and chemical evaluations of under-investigated medicinal plants from this area, with the aim of providing scientific data to support the development of innovative anti-inflammatory herbal products for nutraceutical and cosmetic applications. Among several plants which were screened for their anti-inflammatory activities, the present study highlights the results of a bio-guided fractionation of one of them, Luzula sylvatica, a plant from the Juncaceae family. We demonstrated the activity of the crude methanolic extract and some fractions on several targets with chemical and biological tests and isolated 9 products, mainly from the phenanthrene family. Among them 4 new natural compounds were identified. Finally, biological tests were performed on isolated products mainly on ROS and cytotoxicity in order to exhibit their potential as anti-inflammatory drugs.