C K Ashok Kumar
Sree Vidyanikethan College of Pharmacy, India
Title: Formulation and Development of Finger Millet Based Functional Foods for Prevention of Osteoporosis among Women
Biography
Biography: C K Ashok Kumar
Abstract
Statement of the Problem:
Osteoporosis is a Universal Medical problem, more predominant in menopause women and it is generally accepted that the main causes are estrogen deficiency aging and of certain nutritional elements. This disease is characterized by low bone mass and deterioration of bone tissue. This leads to increased bone fragility and risk of fractures. Though several pharmaceutical formulations have come out, not much success has been achieved because women after menopause stage encounter problems of low absorption of calcium which leads to osteoporosis and this problem will lead to replacement of bone structure such as knee cap. Based on the above data in this study followed a new working hypothesis to absorb more calcium from prepared functional food which was prepared by calcium rich finger millet with bioactive peptides.
Methodology & Theoretical Orientation:
Finger millet based functional food was prepared by adding trypsin hydrolyzed whey protein concentrate and soya protein along with required amount of caseinophospho peptides were mixed with germinated finger millet powder followed by vacuum drying. For analysis, 450 women of villages in and around Chandragiri mandal, Andhra Pradesh, India with a mean age of 35.5 ± 70.5 were selected and screened for osteoporosis/ osteopenia with Dual-Energy X-Ray Absorptiometry (DEXA bone densitometry). In the final analytical sample, 350 osteoporotic women were selected in this study based on their DEXA T score values (T<-2.5). To the selected osteoporotic women the prepared calcium rich functional food was given daily up to 6 months along with their normal diet. The improvement of BMD (T score) was assessed again using DEXA bone densitometry.
Findings
In total 350 subjects, 280 subjects shown a significant change (p ≤0.05) in their bone mineral density T score values (Mean T score values -1±-1.6) compared to their old T score values (-5.5±2.5) after taking of this prepared functional food and also noticed an improvement in their health condition.
Conclusion & Significance:
The data obtained from this study support that intake of a finger millet based nutraceutical functional food with a bioactive peptides of casein, whey proteins and soya proteins enhances the calcium absorption in osteoporotic women and it could be useful for prevailing osteoporosis in women.