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S Mohanalakshmi

Sree Vidyanikethan College of Pharmacy, India

Title: Ameliorative potential and molecular modulation of various fractions of Girardinia heterophylla roots on lipid profile and oxidative stress in high fat diet and streptozotocin induced diabetes

Biography

Biography: S Mohanalakshmi

Abstract

The present study was aimed to investigate the possible ameliorative potential and molecular modulation of various fractions of Girardinia heterophylla (Gh) roots at the doses level of (200 mg/kg b.w.p.o) on lipid profile and oxidative stress in high Fat Diet and Streptozotocin Induced diabetes in rats. Male Wistar rats were divided into six groups, consisting of six animals’ each.The effect of  fractions of Gh on blood glucose, serum lipid profile like total cholesterol (TC), triglyceride (TG) and, serum markers  such as ALP, AST, ALT and estimation of antioxidant parameters like Superoxide dismutase (SOD), Catalase (CAT) were measured in all experimental groups. Body weight and liver glycogen levels were also additionally evaluated. Supplementation of fractions of Girardinia heterophylla by gavage elicited significant antihyperglycemic and hypolipidemic effects (p<0.05). The fractions were also found to be significantly effective (p<0.05) on recovery of altered biochemical parameters like ALP, AST, ALT and decreased body weight in treated animals. Moreover this supplementation significantly improved the antioxidant status (p<0.05)  and increases the glycogen level in liver (9.65± 0.17) as compared to diabetic control (5.42±0.17).Moreover, Histopathological studies of pancreas and liver in diabetic and treated groups  substantiate the cyto protective action of Girardinia heterophylla. In conclusion, ethanol fractions of Girardinia heterophylla offers promising antidiabetic and anti hyperlipedemic and antioxidant potential that may be mainly attributed to its potent antioxidant properties.